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Japanese Journal of Clinical Pharmacology and Therapeutics
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Japanese Journal of Clinical Pharmacology and Therapeutics
35
- Examples of Pharmacokinetics, Pharmacodynamics and Trial Simulation in Drug Development
- The Value of Drug Therapy: Past, Present and Future
- JPGC Activities for Pilot PGx Clinical Research
- Experience with the new regulatory requirements for Phase 1 in the UK.
- No significant circadian variation of QTc interval and dispersion in healthy young men: An analysis of 440 standard 12-lead electrocardiograms
- Safety assurance of intragastric pH monitoring in clinical trials by standardized operations
- Subtype-specific inhibition of .ALPHA.1-adrenergic receptors by carvedilol
- The effect of ingestion time interval on the interaction between erythromycin and midazolam
- Prediction of total propofol clearance from in vitro study using human kidney and liver
- Recent advances of clinical pharmacology: Toxicogenomics
- Design and clinical application of receptors protein microarrays
- Role of Tissue Plasminogen Activator in Drug Dependence Induced by Morphine
- New mechanism in opioid receptor signal transduction
- Clinical Pharmacology and Regulatory Science: As the View from the Administration
- New Mechanisms of Action of NSAIDs: Possible Link to Clinical Evidence
- Clinical pharmacology and regulatory Science: As the view from the pharmaceutical company in Japan
- Postantibiotic effects of amikacin in patients with respiratory tract infections
- The effect of selective inducible nitric oxide synthase inhibitor on cytochrome P450 metabolism enzymes in BCG-immune liver damage in mice
- The inhibitory effect of Benzbromarone on pharmacokinetics of Losartan in relation to genetic polymorphism of CYP2C9
- BDNF (brain-derived neurotrophic factor)-induced aberrant sprouting of neurites and target-selective maturation of inhibitory synapses
- Dynamics and molecular mechanisms of neural network formation
- Search for neuroprotective metabolomes-low molecular weight substances preventing neurodegeneration
- Methodology of Research on the Effective Components and their Effecting Mechanism of the Plant Medicines
- Pharmacological study of LXT-101, a new potent gonadotropin-releasing hormone antagonist
- The discovery and study of aquaporin-1 inhibitors
- Effects of GABA on the activity of isolated toad heart
- Variations of coronary blood flow and oxygen metabolism during acute myocardial ischemia and effects of Hydroxysafflor Yellow A in dogs
- Effects of scallop skirt GAG on the proliferation induced by basic fibroblast growth factor in rabbit vascular smooth muscle cells
- Effects of doxazosin enantiomers on blood pressure and bladder pressure in anesthetized rats
- Research on the regulation functions of the effective components of QINGKAILING on the endothelial cells in ischemia damage
- Expressions of ICAM-1 and VEGF in macrophage-derived foam cells and the effects of Ginkgo biloba extract
- Effect of hyperlipidemia on the ionic currents in cardiac ventricular myocytes of rats
- The effects of ZSZ on polymorphonuclear soakage during myocardium ischemia and reperfusion injury
- Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression
- HMG-CoA reductase inhibitor, pitavastatin decreased adipose tissue of spontaneously hypertensive hyperlipidemic rats with sucrose-induced diabetes
- The Rho kinase inhibitor Y-27632 antagonizes the positive inotropic effect and increase in Ca2+ transients induced by endothelin-1 in rabbit ventricular myocardium
- Pharmacologic study of ohmefentanyl stereoisomers
- Effect of Schisandra Fruit decoction on sleep phase in freely moving rats
- Neuroprotective effects of phenylethanoid glycosides from Cistanches salsa against MPTP-induced dopaminergic toxicity in C57 mice
- Effects of Capsule Yi-Zhi on learning and memory disorder and beta-amyloid peptide induced neurotoxicity in rats
- Chinese Herb component SSY-P3 protects against abnormality in Animal Models of Alzheimer's disease
- Therapeutic effects of Hydroxysafflor yellow A on focal cerebral ischemic injury in rats and its primary mechanisms
- The unique nootropic mechanisms of ginsenoside Rg1
- Effect of ginsenoside Re on the spatial learning and memory impairment of aged mice and rats
- Protective effects of Salvianolic acid B on beta-amyloid induced nurotoxicity
- The effects of cholalic acid and jasminoidin and their compatibility on cascade of damage of cerebral ischemia
- The neuroprotection effects of aspirin on cerebral ischemia-reperfusion in rats
- Differential gene expression of rat focal ischemia brain treated with baicalin and gardenin
- Anti-allodynic effect of N0216 in experimental animal models of neuropathic pain
- Interleukines involved the neuroimmunomodulation pathway underlying cognitive enhancement of Liuwei Dihuang decoction
- Synaptic activity and ion channel character of layer 2/3 pyramidal neurons in rat parietal cortex by whole-cell recording in vivo
- Pharmacological effects of St. John's wort in mice and its interaction with fluvoxamine
- Ganglioside/CaMKII signal inducing cdc42 mediated neuronal actin reorganization
- Integration: a novel method to evaluate voltage-dependent transient outward K+ currents in pharmacology
- Inhibition of human mesangial cell proliferation by pharmacological blockage of volume-regulated chloride channels in vitro
- Genistein inhibited hypoxia inducible factor 1.ALPHA. expression induced by hypoxia and cobalt chloride in human retinal pigment epithelium cells
- Genistein inhibited retinal neovascularization and expression of vascular endothelial growth factor and hypoxia inducible factor 1.ALPHA. in a mouse model of oxygen-induced retinopathy
- Curcumin-mediated downregulation of chemokine mRNA expression is associated with radioprotection of cutaneous tissues
- Protective effect of hypoxia-inducible factor1 related peptide on chemical hypoxia-induced injury in PC12 cells
- Dual Regulation by delta Opioid Receptor Agonists on the Delayed Rectified Potassium Channels in NG108-15 Cells
- Effects of glucosides of Chaenomeles Speciosa on arthritis rats and G protein-coupled signal transduction pathway of synoviocytes
- Toxic Interactions between Miconazole and Disopyramide in Chick Embryos
- The influence of ursodeoxycholic acid on the pharmacokinetics of midazolam in rats
- Polypeptide from Chlamys farreri attenuates damages of mouse thymocytes induced by UVB
- In vitro radical scavenging activity and percutaneous absorption of polypeptide from Chlamys ferreri
- Study on the effect of Chaihuang-Yishen granule in the treatment of renal interstital fibrosis and its mechanism in rats
- Anti-aging effect and its mechanism of indole-2,3-dione in mice
- Study on antitumor effect of isatin
- Effects of Rheum Tanguticum Polysaccharide (RTP) on intestinal epithelial cell repair in vitro
- A modified TCM recipe as an effective approach for developing new anti-diabetic Chinese herbal drugs
- Study on effect of GABA on spontaneous activity of the isolated mouse duodenum
- Protective effect of polypeptides from Chlamys farreri on mouse thymocytes irradiated by 60Co
- High efficient expression of rat Nor-1 in E. coli and generation of anti-NOR-1 antibody
- In vitro protective effect of polypeptide from Chlamys farreri on mouse thymocytes irradiated by ultraviolet A
- Proteomics: the new approach for drug discovery
- Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol
- The single nucleotide polymorphism (SNP) of multi-drug resistance 1 (MDR1, p-glycoprotein) in the Chinese Han population
- Influences of CYP3A5 and MDR1 Gene Polymorphisms on Pharmacokinetics of Midazolam
- The pharmacokinetics of multi-dose intravenous infusion of Gatifloxacin mehanesulfanae injection
- Pharmacokinetics of multi-dose D-polymannuronicate tablets in Chinese healthy volunteers
- Clarithromycin, a CYP3A4 inhibitor, increased the antiparkinsonian effect of cabergoline, an ergote dopamine agonist in the treatment of Parkinson's desease
- Confirmed ST Level Change Differences with administration of Pilsicainide or Disopyramide between Epicardium and Endocardium in RV outflow with Brugada Syndrome Patient
- The role of active metabolites in the pharmacodynamics of quazepam
- A simple individualized method for 6-mercaptopurine in ALL children
- The Study on effect of Tripterygium wilfordii Glycosis by peripheral blood mononuclear cells from proteinuric patients
- Drug-induced renal impairment: clinical and pathological analysis of 57 cases in Kunming
- Inhibitory effect of polypeptide from Chlamys farreri on ultraviolet A-induced oxidative damage on human skin fibroblasts in vitro
- Antirival effect of Oenanthe javanica flavone in human and duck hepatitis B virus infection models
- Growth and MMPs inhibition Effects of BBSKE on human highly metastatic cells, PG-BE1
- ECG QT interval variation by physiological load in healthym ale volunteer-Exploration for substitutional positive control, considering ICH-E14 guideline
1
- Characteristics of gefitinib-acquired resistant non-small cell lung cancer cell lines
- Incidence of gingival overgrowth induced by calcium channel blocker
- Bioequivalence study and evaluation study for absorption from oral cavity of lansoprazole fast disintegrating tablet in healthy subjects
- ESTIMATING THE STARTING DOSE IN HUMANS RECENT DEVELOPMENTS
2
- Transporter; 1. Present Status and Future Perspective of Transporters
- Transporter; 2. The Pharmacological Characterization of the Organic Anion Transpoter (OATP) Family
- Transporter; 3. Clinical Pharmacokinetic Roles of Peptide Transpoters (PEPT1 and PEPT2)
- Transporter; 4. Organic Anion Transporter (OAT)
- Transporter; 5. Organic Cation/Carnitine Transpoter, OCTs and OCTNs
- Transporter; 6. The Role of MRP in Human Disease
- Transporter; 7. Multidrug Resistance Transporters: Multidrug Resistance to Anticancer Agents
- Abnormal Elevation of Serum ALT Level Induced by Multiple Administrations of Unfractionated Heparin in Healthy Japanese Volunteers
- Drug-Induced Hepatotoxicity: Two Cases of Acute Hepatotoxicity Caused by Either Anticonvulsants or Diet Medicine
- The Role of the Translational Research Coordinator and Trials to Maintain Medical Ethics in Translational Research: Focus on Activities Related to Informed Consent
- Individual specificity of pharmacological action and pharmacodynamics.
3
- Pharmacogenomics and Translational Research
- Fostering Successful Translational Research: A Sound Infrastructure for Clinical Research Is Critical
- Promoting the Translational Research from the View Point of Academia
- Acceleration of Translational Research: From the Aspect of Pharmaceutical Industries
- Examination About Adverse Events Detection and Its Execution Degree in Investigations Right After Marketing; Consideration by Investigation of the BENET TABLETS
- Parmacogenomics of Long QT Syndrome
- CRC Education Course 9
4
- Pharmacodynamics of Three Different Routes of Administration of Natural Type Interferon-.BETA. in Healthy Volunteers
- Activities of SMO's in Japan: A Survey of Japan Association of Contract Institutes for Clinical Pharmacology
- New Approach to the Treatment of Hyperphenylalaninemia: Tetrahydrobiopterin Supplementation Therapy
- Microdose Pharmacokinetic Study
- Medication Teaching and Compliance in Clinical Trial
- Infection Diseases and Malignant Tumors: Therapeutic Guidelines and Clinical Pharmacology 1. Statistical Consideration for Therapeutic Guidelines
- Infection Diseases and Malignant Tumors: Therapeutic Guidelines and Clinical Pharmacology 2. Guidelines for the Treatment of Infectious Diseases
- Infection Diseases and Malignant Tumors: Therapeutic Guidelines and Clinical Pharmacology 3. PK/PD and TDM for Antimicrobial Agents
- Infection Diseases and Malignant Tumors: Therapeutic Guidelines and Clinical Pharmacology 4. Therapeutic Guidelines for Anticancer Drugs
- Infection Diseases and Malignant Tumors: Therapeutic Guidelines and Clinical Pharmacology 5. Appropriate Use of Antineoplastic Agent: Clinical Application Base on Pharmacokinetics: Pharmacokinetics, Therapeutic Drug Monitoring (TDM)
- Infection Diseases and Malignant Tumors: Therapeutic Guidelines and Clinical Pharmacology 6. mANAGEMENT OF pHARMACISTS ON THE cANCER cHEMOTHERAPY
5
- Effects of Colforsin Daropate Hydrochloride (Adehl Inj.), Anti-Acute Heart Failure Agent, on Adenylate Cyclase-Related Hormone Actions
- Post-Marketing Surveillance of Amrinone (Amcoral Injection 50 100): Special Investigation of Background Risk Factors for Amrinone-Mediated Thrombocytopenia
- Long-Term Combination Therapy with an ACE Inhibitor, Captopril, and an HMG-CoA Reductase Inhibitor, Pravastatin, Is Beneficial for Hypercholesterolemic Hypertensives: an Observational Study
- One Patient which Caused Phenocopy by Internal Use of Antihypertensive Drugs
- CRC Education Course 11 Clinical Trials in Volunteers with Renal or Hepatic Impairment: Objective and Study Design
6
- Clinical Pharmacology of Pediatric Patients: Basic Aspects of Pediatric Pharmacology
- Clinical Pharmacology of Pediatric Patients: Developmental and Therapeutic Pharmacology of Antiepileptic Drugs
- Clinical Pharmacology of Pediatric Patients: Pharmacology of Antibiotics in Pediatrics
- Clinical Pharmacology of Pediatric Patients: Clinical Pharmacology of Theophylline in Childhood Bronchial Asthma
- Pharmacokinetic Evaluation of Anticonvulsants in a Patient with Porphyria
- Evaluation of Deviation from Protocol in Osaka University Hospital How to Reduce the Deviation
- Response of Trial Subjects to the Packing Form of an Investigational Product
- Introduction to a Website Which Makes Results of Clinical Studies Open to Public
- Establishing a Clinical Trial Registry in Japan from a Global Perspective: UMIN-CTR to Open in April 2005
- CRC Education Course: 12: Important Aspects of Clinical Trial in the Elderly
Suppl.
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