Science Links Japan | Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period

Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period

Accession number;07A0130088

Title;Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period

Author;MAEDA TETSUO(POLA Chemical Ind., Inc., JPN) YAMAMOTO TAKUYA(POLA Chemical Ind., Inc., JPN) ISHIKAWA YOKO(POLA Chemical Ind., Inc., JPN) ITO NORIIE(Adobanjen) ARASE SEIJI(Univ. Tokushima, Graduate School, Inst. Health Biosciences, JPN)

Journal Title;Nishinihon Journal of Dermatology

Journal Code:G0894B

ISSN:0386-9784

VOL.69;NO.1;PAGE.81-86(2007)

Figure&Table&Reference;

Pub. Country;Japan

Language;Japanese

Abstract;FGF-5 inhibitors with FGF-5-antagonizing activity may be effective against hair loss, as these inhibitors suppress the transition of hair follicles from the anagen to catagen phase caused by FGF-5. We screened 24 substances for their FGF-5-antagonizing activity using both an FGF receptor-1c-transfected Ba/F3 cell line and the C3H mouse, and finally detected Sanguisorba Officinalis Root Extract (SO extract) as a reliable FGF-5 inhibitor. Topical application of SO extract elongated the anagen period in C3H mice. In addition, in a clinical study using 39 volunteers with hair loss, the SO extract significantly decreased the telogen/anagen hair ratio and the number of shed hairs. This extract showed a high degree of usefulness clinically. These findings suggest that FGF-5-antagonizing activity of SO extract observed in vitro and in vivo is closely related to its clinical effects. (author abst.)