| Accession number;07A0096978 |
| Title;Effect of Extracts Squeezed from Agaricus blazei for High-normal Blood Pressure or Mild Hypertension on Human Blood Pressure |
| Author;INATOMI SATOSHI(Hokuto) OUCHI KENJI(Hokuto) AZUMI YOSHIHITO(Hokuto) KOBAYASHI HITOSHI(Hokuto) TSUCHIDA TAKASHI(Isogochuonoshinkeigekabyoin) |
Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.34;NO.12;PAGE.1295-1309(2006)
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| Figure&Table&Reference;FIG.3, TBL.9, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Extracts squeezed from Agaricus blazei fruits-body(ABFE)contain .GAMMA.-aminobutyric acid(GABA), which expect hypotensive effects in hypertensive persons. We investigated hypotensive effects of A-extract in a double blind trial, 134 adults(averaged 48 years old)with high-normal blood pressure or mild hypertension. The amount of GABA in A-extract prepared 4 groups, which contain placebo(A group), 20mg GABA/50 mL ABFE(B group), 40 mg GABA/50 mL ABFE(C group)and 70mg GABA/50 mL ABFE(D group). All subjects were administrated once dairy for 8weeks. The results revealed that C group significantly decreased diastolic blood pressure(DBP)at 8 weeks in comparison with A group. C group significantly decreased systolic blood pressure(SBP)at 6 and 8 weeks and DBP at from 4 to 8 weeks in comparison with A group. D group significantly decreased systolic blood pressure(SBP)at 6 and 8 weeks and DBP at from 2 to 8 weeks in comparison with A group. B and D group increased blood pressure after finished administration of ABFE at once. Furthermore, subjective symptom, objective symptom, and blood examination were not observed in all subjects. These results of this study suggested that ABFE has hypotensive effects in adults with high-normal and mild hypertension, and optimal concentration of GABA is 40mg GABA/50 mL ABFE. (author abst.) |
