The role of hepatic specialist in obesity/diabetes mellitus ambulatory treatment.

Accession number;06A0719391
Title;The role of hepatic specialist in obesity/diabetes mellitus ambulatory treatment.
Author;SEIKE MASATAKA(Oita Univ.)   
Journal Title;Minophagen Med Rev
Journal Code:X0211A
ISSN:0388-4783
VOL.51;NO.4;PAGE.258-260(2006)
Figure&Table&Reference;FIG.4, REF.2
Pub. Country;Japan
Language;Japanese
Abstract;In addition to the present state of the liver disease-specialized ambulatory treatment performed so far in a diabetes mellitus-specialized clinic, the features of fatty liver, present state of non-alcoholic fatty hepatitis (NASH), and the treatment are outlined. Among the 670 abdominal ultrasonic test cases in diabetes mellitus ambulatory treatment during 1 year, fatty liver was 45%, and it was fairly higher than the fatty liver in the detection survey in the Oita district (about 20%). When the clinical progress was observed for a year, in the fatty liver group, there were many events related to lifestyle-related disease. HCV antibody was measured for all new patients, about 200, of diabetes mellitus in this clinic for 3 years. About 3% was positive, and the relationship between HCV infection and diabetes mellitus was indicated. About 60% of the cases, which were diagnosed as fatty liver, and for which the liver biopsy was performed, were NASH, and it was indicated that NASH is not a rare disease state. For the differentiation of NASH and fatty liver, a diagnostic guideline using liver fibrillation marker is required. If a fibrillation marker is normal, it is controlled corresponding to fatty liver. In the treatment, there are diet therapy, exercise therapy and pharmacotherapy, and it is important to control the body weight. Regarding the pharmacotherapy, there are few long-term therapeutic results. The cases in our own experience are shown, and the possibility of preventing the progress by eicosapentaenoic acid is indicated. A liver disease clinic must keep lifestyle-related disease in mind in addition to the conventional viral liver diseases, and it is necessary to understand the importance of the metabolism in the liver for the crisis of lifestyle-related disease.