Effect of Birch (Betula platyphylla Sukatchev var. japonica Hara) Sap on Epidermal Keratinocytes Differentiation.
| Accession number;06A0864959 |
| Title;Effect of Birch (Betula platyphylla Sukatchev var. japonica Hara) Sap on Epidermal Keratinocytes Differentiation. |
| Author;MORIYAMA MASAHIRO(Kose Corp., JPN) |
Journal Title;Fragr J
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Journal Code:G0987B
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ISSN:0288-9803
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VOL.34;NO.10;PAGE.24-29(2006)
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| Figure&Table&Reference;FIG.7, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Birch sap has been widely used as an effective drink against an anti-fatigue and anti-stress. However, beneficial effects of birch sap on skin such as a cosmetic usage have not been known entirely. In this study, we investigated the effect of birch (Betula platyphylla Sukatchev var. japonica Hara) on human skin, especially epidermal keratinocytes differentiation apparently. We assessed two epidermal differentiation makers, filaggrin is a precursor protein of NMF (Natural Moisturizing Factor) and involucrin is one of a precursor protein of CE (Cornified Cell Envelope) related to barrier function. We evaluated production of these proteins on birch sap applied to keratinocytes. As the results, birch sap not only accelerated the production of filaggrin and involucrin, but also increased these mRNA expression levels. This study suggested that birch sap would be able to control of epidermal differentiation with induction of filaggrin and involucrin expression. This induction by birch sap gives appropriate epidermal differentiation and skin moisture effect on cosmetic usage. (author abst.) |
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