Clinical Evaluation of the Topical Application of Magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol) for Hyperpigmentation on the Face
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Accession number;06A0504976
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| Title;Clinical Evaluation of the Topical Application of Magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol) for Hyperpigmentation on the Face |
| Author;
TAKEDA KATSUYUKI
(Univ. of Tokushima)
ARASE SEIJI
(Univ. of Tokushima)
SAGAWA YOSHIAKI
(Sagawaiin)
SHIKADA YUKO
(Shikadahifuka)
OKADA HIROYUKI
(Okadahifukakurinikku)
WATANABE SHIN'ICHI
(Dep. Medicine, Teikyo Univ., JPN)
YOKOTA TOMOHIRO
(Kanebokeshohin)
IKEMOTO TAKESHI
(Kanebokeshohin)
KAKISHIMA HIROSHI
(Kanebokeshohin)
MATSUO TOORU
(Kanebokeshohin)
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Journal Title;Nishinihon Journal of Dermatology
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Journal Code:G0894B
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ISSN:0386-9784
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VOL.68;NO.3;PAGE.293-298(2006)
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| Figure&Table&Reference;REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The lightening effects of Magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol) on hyperpigmentation on the face, such as melasma, senile lentigo, etc., were studied in 51 female patients. The formulation containing 0.5% Magnolignan was topically applied to pigmented areas on the face for 6 months. The score representing the degree and area of pigmentation was significantly improved during the test period. The .DELTA.L values also were significantly improved after 6 months. Results of a questionnaire given after the 6-month test period indicated that a large proportion of subjects strongly felt that the condition of the various pigmentations had improved and that the formulation was of high quality for daily use. The topical application of 0.5% Magnolignan was confirmed to be effective in lightening not only pigmented skin lesions but also non-pigmented healthy skin. No unfavorable skin reaction was observed during the test period. In conclusion, the formulation containing 0.5% Magnolignan was found to be safe and effective for topical application to treat various skin pigmentations. (author abst.) |
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