| Accession number;06A0274765 |
| Title;Solubility Prediction of Paracetamol in Binary and Ternary Solvent Mixtures Using Jouyban-Acree Model |
| Author;JOUYBAN ABOLGHASEM(Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences) CHAN HAK-KIM(Faculty of Pharmacy, The University of Sydney) CHEW NORA YAT KNORK(Faculty of Pharmacy, The University of Sydney) KHOUBNASABJAFARI MARYAM(Kimia Research Institute) ACREE, JR. WILLIAM EUGENE(Department of Chemistry, University of North Texas) |
Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.54;NO.4;PAGE.428-431 (J-STAGE)(2006)
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| Figure&Table&Reference;FIG.3, TBL.4, REF.18 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The Jouyban-Acree model has been used to predict the solubility of paracetamol in water-ethanol-propylene glycol binary and ternary mixtures based on model constants computed using a minimum number of solubility data of the solute in water-ethanol, water-propylene glycol and ethanol-propylene glycol binary mixtures. Three data points from each binary solvent system and solubilities in neat solvents were used to calculate the binary interaction parameters of the model. Then the solubility at other binary solvent compositions as well as in a number of ternary solvents were predicted, and the mean percentage deviation (.+-.S.D.) of predicted values from experimental solubilities was 7.4(.+-.6.1)%. (Author abst.) |
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