Contribution of Bystander Effects in Radiation Induced Genotoxicity
| Accession number;06A0107596 |
| Title;Contribution of Bystander Effects in Radiation Induced Genotoxicity |
| Author;ZHOU HONGNING(Columbia Univ. Medical Center, New York, Usa) SUZUKI MASAO(National Inst. Of Radiological Sci., Chiba, Jpn) PERSAUD RUDRANATH(Columbia Univ. Medical Center, New York, Usa) GILLISPIE JOSEPH(Columbia Univ. Medical Center, New York, Usa) RANDERS-PEHRSON GERHARD(Columbia Univ. Medical Center, New York, Usa) HEI TOM K.(Columbia Univ. Medical Center, New York, Usa) |
Journal Title;Acta Med Nagasaki Ensia
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Journal Code:X0952A
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ISSN:0001-6055
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VOL.50;NO.Supplement 1;PAGE.73-77(2005)
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| Figure&Table&Reference;REF.42 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The controversial use of a linear, no threshold extrapolation model for low dose risk assessment is based on the accepted dogma that the deleterious effects of ionizing radiation such as mutagenesis and carcinogenesis are attributable mainly to direct damage to DNA. However, this extropolation was challenged by the recent reports on the bystander phenomenon. The bystander effect contributes to this debate by implying that the biological effects of low doses, where not all cells are traversed by a charged particle, are amplified by the transfer of factors to un-irradiated neighbors. This interested phenomenon implies that a linear extrapolation of risks from high to low doses may underestimate rather than over estimate low dose risks. Together with some radiation-induced phenomena such as adaptive response and genomic instability, the radiobiological response at low doses is likely to be a complex interplay among many factors. (author abst.) |
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