Xanthine Oxidase Inhibitors from the Heartwood of Vietnamese Caesalpinia sappan
| Accession number;05A0685097 |
| Title;Xanthine Oxidase Inhibitors from the Heartwood of Vietnamese Caesalpinia sappan |
| Author;NGUYEN MAI THANH THI(Inst. Of Natural Medicine, Toyama Medical And Pharmaceutical Univ.) AWALE SURESH(Inst. Of Natural Medicine, Toyama Medical And Pharmaceutical Univ.) TEZUKA YASUHIRO(Inst. Of Natural Medicine, Toyama Medical And Pharmaceutical Univ.) TRAN QUAN LE(Inst. Of Natural Medicine, Toyama Medical And Pharmaceutical Univ.) KADOTA SHIGETOSHI(Inst. Of Natural Medicine, Toyama Medical And Pharmaceutical Univ.) |
Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.53;NO.8;PAGE.984-988 (J-STAGE)(2005)
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| Figure&Table&Reference;FIG.4, TBL.3, REF.18 |
| Pub. Country;Japan |
| Language;English |
| Abstract;From the MeOH extract of Vietnamese Caesalpinia sappan, a novel biogenetically exclusive benzindenopyran, with a new carbon framework, neoprotosappanin (1), and a new compound, protosappanin A dimethyl acetal (3), were isolated together with protosappanin E-2 (2), neosappanone A (4), and 13 previously reported phenolic compounds (5-17). Their structures were elucidated on the basis of spectroscopic data. Compounds 1-4, 7, 13, and 15-17 showed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and sappanchalcone (17) showed the most potent activity with an IC50 value of 3.9 .MU.M, comparable to that of positive control allopurinol (IC50, 2.5 .MU.M). The kinetic study of these inhibitors indicated that they are competitive inhibitors, the same as allopurinol, except for 1 and 16 which are noncompetitive inhibitors. (Author abst.) |
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