Modification of Chitosan with Bioactive Oligosaccharide
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Accession number;05A0615751
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| Title;Modification of Chitosan with Bioactive Oligosaccharide |
| Author;
LI XUEBING
(Hokkaido Univ., Fac. of Sci.)
WATANABE SHIN'YA
(Univ. Shizuoka, School of Pharmaceutical Sci., JPN)
SUZUKI TAKASHI
(Univ. Shizuoka, School of Pharmaceutical Sci., JPN)
SUZUKI YASUO
(Univ. Shizuoka, School of Pharmaceutical Sci., JPN)
WATANABE MIHO
(International Medical Center of Japan, JPN)
NATORI YASUHIRO
(International Medical Center of Japan, JPN)
NISHIKAWA KIYOTAKA
(International Medical Center of Japan, JPN)
KITA EIJI
(Naraken'idai Saikingaku)
MONDE KENJI
(Hokkaido Univ., Fac. of Sci.)
NISHIMURA SHIN'ICHIRO
(Hokkaido Univ., Fac. of Sci.)
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Journal Title;Chitin and Chitosan Research
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Journal Code:L2321A
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ISSN:1340-9778
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VOL.11;NO.2;PAGE.120-121(2005)
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| Figure&Table&Reference;FIG.1, REF.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;It is now well established that cell surface carbohydrates poly key roles in a variety of biological processes such as intercellular recognition and immune response. Such carbohydrate recognition can be clearly illustrated by microbial adhesion to host cell at the first stage toward infection. For example, the colonization of influenza virus to its target cell is mediated by the binding to the cellular sialooligosaccharide such as sialyllactose; Escherichia coli O157 are known to recognize the sugar moiety of globotriaosylcerimide. Based on these biological findings, various types of synthetic polymers with high affinity to microbial pathogens have been developed as microbial blockers by clustering "antennary sugars" on appropriate macromolecular scaffolds. In this study, we selected chitosan as the key scaffolding structure because of its excellent biological properties such as biocompatibility and antimicrobial activity. The efficient synthesis and bioactivities of several such sugar-chitosan conjugates will be reported. (author abst.) |
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