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Quantitative Insulin Sensitivity Check Index Is a Useful Indicator of Insulin Resistance in Japanese Metabolically Obese, Normal-Weight Subjects with Normal Glucose Tolerance

Accession number;05A0437158

Title;Quantitative Insulin Sensitivity Check Index Is a Useful Indicator of Insulin Resistance in Japanese Metabolically Obese, Normal-Weight Subjects with Normal Glucose Tolerance

Author;KATSUKI AKIRA(Dep. Of Internal Medicine, Div. Of Diabetology And Endocrinology, Mie Univ. School Of Medicine) URAKAWA HIDEKI(Dep. Of Internal Medicine, Div. Of Diabetology And Endocrinology, Mie Univ. School Of Medicine) GABAZZA ESTEBAN C.(Div. Of Pulmonary And Critical Care Medicine, Mie Univ. School Of Medicine) MURASHIMA SHUICHI(Dep. Of Radiology, Mie Univ. School Of Medicine) NAKATANI KANAME(Dep. Of Lab. Medicine, Mie Univ. School Of Medicine) TOGASHI KENJI(Dep. Of Health And Physical Education, Mie Univ. School Of Education) YANO YUTAKA(Dep. Of Internal Medicine, Div. Of Diabetology And Endocrinology, Mie Univ. School Of Medicine) ADACHI YUKIHIKO(Dep. Of Internal Medicine, Div. Of Diabetology And Endocrinology, Mie Univ. School Of Medicine) SUMIDA YASUHIRO(Dep. Of Internal Medicine, Div. Of Diabetology And Endocrinology, Mie Univ. School Of Medicine)

Journal Title;Endocr J

Journal Code:F0625A

ISSN:0918-8959

VOL.52;NO.2;PAGE.253-257 (J-STAGE)(2005)

Figure&Table&Reference;FIG.1, TBL.1, REF.23

Pub. Country;Japan

Language;English

Abstract;To clarify whether quantitative insulin sensitivity check index (QUICKI) is useful as an indicator of insulin resistance in Japanese metabolically obese, normal-weight (MONW, body mass index (BMI) <25 and visceral fat area (VFA) .GEQ.100 cm'2' by abdominal computed tomography scanning) subjects with normal glucose tolerance (NGT). Insulin resistance was measured by QUICKI and euglycemic hyperinsulinemic clamp study (clamp IR) in 27 MONW and 27 normal subjects (BMI <25 and visceral fat area <100 cm'2'). QUICKI (P<0.01) and clamp IR (p<0.01) were significantly decreased in MONW subjects compared with normal subjects. QUICKI was significantly associated with VFA [MONW subjects: r = -0.459, p<0.02; all (MONW and normal) subjects: r = -0.506, p<0.0001] and with the serum levels of triglycerides (MONW subjects: r = -0.386, p<0.05; all subjects: r = -0.505, p<0.001) in MONW and all subjects. There were significant correlations between clamp IR and VFA (MONW subjects: r = -0.562, p<0.01; all subjects: r = -0.575, p<0.0001), fasting serum levels of insulin (MONW subjects: r = -0.673, p<0.001; all subjects: r = -0.619, p<0.0001) or serum levels of triglycerides (MONW subjects: r = -0.485, p<0.02; all subjects: r = -0.565, p<0.0001) in MONW and all subjects. QUICKI was significantly correlated with clamp IR in MONW (r = 0.754, p<0.0001) and in all subjects (r = 0.568, p<0.0001). QUICKI may be an useful method for assessing insulin resistance in Japanese MONW subjects with NGT. (Author abst.)