Morning Rise in Blood Pressure Is a Predictor of Left Ventricular Hypertrophy in Treated Hypertensive Patients
| Accession number;05A0258662 |
| Title;Morning Rise in Blood Pressure Is a Predictor of Left Ventricular Hypertrophy in Treated Hypertensive Patients |
| Author;IKEDA T(Nippon Telegraph And Telephone Corp. (ntt), Tokyo, Jpn) GOMI T(Nippon Telegraph And Telephone Corp. (ntt), Tokyo, Jpn) SHIBUYA Y(Nippon Telegraph And Telephone Corp. (ntt), Tokyo, Jpn) MATSUO K(Nippon Telegraph And Telephone Corp. (ntt), Tokyo, Jpn) KOSUGI T(Nippon Telegraph And Telephone Corp. (ntt), Tokyo, Jpn) OKU N(Nippon Telegraph And Telephone Corp. (ntt), Tokyo, Jpn) UETAKE Y(Nippon Telegraph And Telephone Corp. (ntt), Tokyo, Jpn) KINUGASA S(Nippon Telegraph And Telephone Corp. (ntt), Tokyo, Jpn) FURUTERA R(Nippon Telegraph And Telephone Corp. (ntt), Tokyo, Jpn) |
Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.12;PAGE.939-946(2004)
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| Figure&Table&Reference;FIG.3, TBL.4, REF.27 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The echocardiography of 297 patients who had been receiving the amordibine monotherapy over 1 year was evaluated in order to evaluate the relationship between LV weight and home blood pressure. Early morning hypertension group with early morning home systolic blood pressure (HSBS) .GEQ. 135mmHg and evening HSBS < 135mmHg had significantly bigger LV weight index (LVMI) with the increase in HOMA-IR (fast blood sugar (mg/dl)* fast insulin concentration (mU/ml) than the good control group. The good control group was both morning and evening HSBS < 135mmHg, and then, it was a group with LVMI which was almost equal to bad control group with over 135mmHg in morning and evening HSBS. By dividing the group according to the HSBS difference (.DELTA.HSBS) in early morning and evening, it was found that a man with .DELTA.HSBS .GEQ. 10mmHg had significantly bigger LVMI than a man with .DELTA.HSBS .LEQ.10mmHg human. The LVMI increase in these patients was still significant after the compensation for age, sex, amordibine dose, alcohol consumption, BMI, office systolic blood pressure and morning and evening HSBP. In the multivariable analysis, it was decided that .DELTA.HSBS, early morning HSBP, HOMA-IR and age were significant contributing factor for LVMI. This regression model enabled to explain 44.1% of the variability of LMVI. These results indicated that the morning rise in blood pressure is an influential predictor of the left ventricular hypertrophy. |
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