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A Clinical Study of Azithromycin Hydrate for Acute Sinusitis with Special Regard to Methods of Oral Administration

Accession number;04A0655800

Title;A Clinical Study of Azithromycin Hydrate for Acute Sinusitis with Special Regard to Methods of Oral Administration

Author;FUKAZAWA KEIJIRO(Fac. Medicine, Hyogo Coll. Medicine, JPN) TAKAYASU SADAMU(Fac. Medicine, Hyogo Coll. Medicine, JPN) HASHIMOTO YOSHITERU(Fac. Medicine, Hyogo Coll. Medicine, JPN) FUJII MEGUMI(Meiwa Hosp.) OKUNAKA MIEKO(Meiwa Hosp.) IWATA AYAKO(Amagasakichuobyoin Jibiinkoka) SAKAGAMI MASAFUMI(Fac. Medicine, Hyogo Coll. Medicine, JPN)

Journal Title;Practica Otologica (Kyoto)

Journal Code:G0710A

ISSN:0032-6313

VOL.97;NO.9;PAGE.833-838(2004)

Figure&Table&Reference;FIG.4, TBL.3, REF.10

Pub. Country;Japan

Language;Japanese

Abstract;Azithromycin hydrate (AZM) is a new macrolide antimicrobial. In this study, we evaluated the clinical efficacy of AZM for acute sinusitis. The patients were randomly divided into two groups. Twenty-five patients (Group A) were given a daily 500-mg oral dose of AZM for 3 days, and 26 patients (Group B) were given the same dose of AZM two times with a 1-week interval. The clinical efficacy rate was 85.2% in Group A and 88% in Group B, and there was no significant difference in the efficacy rates between these groups. These findings suggested that AZM was useful for the treatment of acute sinusitis and that a 500-mg oral dose of AZM for 3 days should be sufficient. (author abst.)