| Accession number;04A0542887 |
| Title;Antiviral Effects of Aciclovir Injectable Formulation (Acirovec and Zovirax for i.v. Infusion) against Herpes Simplex Virus Type 1 in vitro and in vivo |
| Author;OGURA TAKEHARU(Sawai Pharm. Co., Ltd.) OTSUBO YOSHIKAZU(Sawai Pharm. Co., Ltd.) UEDA HARUYASU(Hyogo Coll. Medicine, Inst. Advanced Medical Sci., JPN) OKAMURA HARUKI(Hyogo Coll. Medicine, Inst. Advanced Medical Sci., JPN) |
Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.32;NO.6;PAGE.349-352(2004)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The present study reports the antiviral effect of Acirovec for i.v. infusion, a generic aciclovir (ACV) injectable formulation, in comparison with Zovirax. In vitro activities of Acirovec and Zovirax against herpes simplex virus type 1 (HSV-1) were determined by plaque reduction assay. The IC50 values of Acirovec and Zovirax were 0.106 and 0.112 .MU.g/mL, respectively. In vivo antiviral effects of Acirovec and Zovirax were studied on experimental murine model of HSV-1 infection. Female BALB/c mice were intraperitoneally inoculated with 107 PFU of HSV-1. Treatments of Acirovec and Zovirax were initiated 2h after infection of HSV-1 and were continued until day 7. The treatments with both drugs at 10 mg/kg per day improved the survival rates of HSV-1 infection compared with those of vehicle-treated mice. There was no significant difference between each drug in survival rate. Our study demonstrated that the protective effect of Acirovec was equivalent to that of Zovirax. (author abst.) |
