Suppressive Effect of Oolong Tea Polymerized Polyphenols-enriched Oolong Tea on Postprandial Serum Triglyceride Elevation

Accession number;04A0542885
Title;Suppressive Effect of Oolong Tea Polymerized Polyphenols-enriched Oolong Tea on Postprandial Serum Triglyceride Elevation
Author;HARA YUJI(Suntory Ltd., JPN)   MORIGUCHI SHIGEO(Suntory Ltd., JPN)   KUSUMOTO AKI(Suntory Ltd., JPN)   NAKAI MASAAKI(Suntory Ltd., JPN)   ONO YOSHIKO(Suntory Ltd., JPN)   ABE KEIICHI(Suntory Ltd., JPN)   OTA HIROMI(Suntory Ltd., JPN)   SHIBATA HIROSHI(Suntory Ltd., JPN)   EGAWA KAZUTADA(Nihombashiegawakurinikku)   
Journal Title;Japanese Pharmacology & Therapeutics
Journal Code:Z0947A
ISSN:0386-3603
VOL.32;NO.6;PAGE.335-342(2004)
Figure&Table&Reference;FIG.6, TBL.2, REF.23
Pub. Country;Japan
Language;Japanese
Abstract;Objectives: A randomized double-blind placebo-controlled crossover study was conducted on 22 subjects with borderline and mild hyperlipidemia to evaluate the suppressive effect of OTPP (oolong tea polymerized polyphenols) enriched oolong tea beverage on postprandial serum triglyceride elevation. Methods: Subjects were Japanese adult male and female whose serum triglyceride levels were between 100-250 mg/dL. Subjects were divided into two groups randomly, and ingested a high fat meal (40 g fat) and test beverage (OTPP enriched oolong tea beverage or the placebo beverage). Serum triglyceride elevation was determined at 0, 1, 2, 3, 4, 5 hr after ingestion of the meal. Results: Postprandial serum triglyceride elevation was significantly suppressed at 3 hr and 5 hr after a high fat meal ingestion by taking OTPP enriched oolong tea beverage compared with the placebo beverage. Postprandial chylomicron elevation was also significantly decreased at 2 hr, 3 hr and 5 hr after a high fat meal ingestion. .DELTA. AUCs (areas under the curves) of both serum trigliceride and chylomicron levels were significantly decreased by 18.3% (p<0.05) and 29.9% (p<0.01), respectively. There were no significant differences in both LDL and total cholesterol levels. No adverse effects were observed in taking OTPP enriched oolong tea beverages. Conclusions: OTPP enriched oolong tea beverage has remarkable suppressive effect on the postprandial serum triglyceride elevation in the subjects with borderline and mild hyperlipidemia, suggesting that this beverage is useful for risk reduction of life-style related diseases. (author abst.)