Use of Hypertonic Lactated Saline Attenuates Impairment of Pulmonary Oxygenation in Patients with Extensive Burn and Inhalation Injuries

Accession number;04A0208954
Title;Use of Hypertonic Lactated Saline Attenuates Impairment of Pulmonary Oxygenation in Patients with Extensive Burn and Inhalation Injuries
Author;MASUDA YOSHIKI(Asahikawa Red Cross Hospital, JPN)   IMAIZUMI HITOSHI(Sapporo Medical Univ., Hospital, JPN)   SHICHINOHE YASUO(Asahikawa Red Cross Hospital, JPN)   NAMIKI AKIYOSHI(Sapporo Medical Univ., School of Medicine, JPN)   
Journal Title;Hiroshima Journal of Anesthesia
Journal Code:S0305A
ISSN:0385-1664
VOL.39;NO.2;PAGE.39-43(2003)
Figure&Table&Reference;FIG.3, TBL.3, REF.22
Pub. Country;Japan
Language;Japanese
Abstract;Objective: The present study was undertaken to assess the effect of fluid balance during the first 24hrs of resuscitation using either lactated Ringer's (LR) solution or hypertonic lactated saline (HLS) on pulmonary oxygenation in patients with an extensive burn and inhalation injuries. Patients and Methods: Twenty patients with extensive burn and inhalation injuries were divided into two groups according to the resuscitation fluid used. Patients in the LR group and HLS group were resuscitated with LR solution and HLS, respectively, in the early postburn period. The respiratory index (A-aDO2/PaO2: RI), total fluid volume used over a period of 8 hours, leukocyte count and serum protein concentration were determined every 8 hours during a period of 24 hours after injury. Thereafter, RI, leukocyte count and serum protein concentration were also determined every 24 hours until 7 days after injury. Results: The demographic characteristics of the patients in the two groups were not different. The total fluid volume administered per burn index (BI) in the LR group was significantly greater than that in the HLS group during the first 16 hours after injury. RI in the LR group was significantly higher than that in the HLS group at 48 and 72 hours after injury. Maximal leukocyte count was not correlated with maximal RI in either group. Conclusion: The use of HLS for resuscitation of extensively burned patients complicated with inhalation injury may be associated with an attenuation of impairment of pulmonary oxygenation in the early postburn period. (author abst.)