Meat Protein and Brain Function
| Accession number;04A0022360 |
| Title;Meat Protein and Brain Function |
| Author;HISATSUNE TATSUHIRO(Univ. Tokyo, Graduate School of Frontier Sci., JPN) |
Journal Title;Shokuniku ni kansuru Josei Kenkyu Chosa Seika Hokokusho
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Journal Code:X0296A
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ISSN:
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VOL.21;NO.;PAGE.256-259(2003)
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| Figure&Table&Reference;FIG.2, REF.4 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We studied the effect of Meat Protein as a context of amino acid nutrient on Brain function and regeneration. A series of recent studies have shown that IGF-1, one of growth hormones, plays an important role on the regeneration of nervous system. The blood concentration of IGF-1 is regulated by nutrient condition, especially by the amino acid nutrient. Therefore, Meat Protein could promote neuronal regeneration via the up-regulation of IGF-1 homeostasis. In this study, we used the two formulae: control diet(MF) and Meat Protein-rich(MP) diet. Nestin-GFP mice were fed with each diet for 14 days, and were applied with BrdU on last 10 days, and each brain was dissected out from each mouse. Cerebral slice(40 micron) was cut by cryostat, and each slice was stained with both anti-GFP and anti-BrdU. Number of nestin+ cells per 1mm3 in cerebral cortex of control(MF) group and experimental(MP) group was 442 and 471, respectively. In addition, the frequency for nestin+ dividing cells per total dividing cells in MF group and MP group was 50% versus 72%. These results indicate that Meat Protein promotes the generation of neural precursor cells in mammalian cerebral neocortex, center of our intelligence. Our study suggests that Meat Protein enhances the Brain function and activity by promoting the regeneration of nervous system. (author abst.) |
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