Water Diuresis Promotes Urine Acidification with Decreases in HCO3- Concentration
| Accession number;03A0613180 |
| Title;Water Diuresis Promotes Urine Acidification with Decreases in HCO3- Concentration |
| Author;KURAMOCHI G(Kariwa County General Hospital, Niigata, Jpn) |
Journal Title;Journal of the Japanese Association of Rural Medicine
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Journal Code:Z0313B
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ISSN:0468-2513
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VOL.52;NO.2;PAGE.184-189(2003)
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| Figure&Table&Reference;FIG.2, REF.17 |
| Pub. Country;Japan |
| Language;English |
| Abstract;It is known that the reabsorption of filtered HCO3- depends on the tubular flow rate in the proximal uniferous tubule. In animal experiments, studies have demonstrated that, when diuresis was induced, the pH of the collecting duct urine decreased, resulting from the decrease in HCO3- concentration with no change in the pCO2 level. The present study was designed to examine changes in urine acidification in humans under a water diuretic state. Urine pH, pCO2 levels, and HCO3- concentration were measured before and after the drinking of water. In 120 minutes after hydration, the urine pH level fell about 0.5pH unit from that before the intake of water. The urine HCO3- concentration coincidentally decreased significantly. However, pCO2 values remained unchanged. These results indicated that also in humans, water diuresis promotes urine acidification, resulting from a decrease in HCO3- concentration with no change in the pCO2 level, which may contribute to the prevention of the loss of plasma HCO3- into the urine when the urine flow rate increases. (author abst.) |
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