Science Links Japan | The D Allele of the Angiotensin-Converting Enzyme Insertion/Deletion (I/D) Polymorphism is a Risk Factor for Type 2 Diabetes in a Population-Based Japanese Sample

The D Allele of the Angiotensin-Converting Enzyme Insertion/Deletion (I/D) Polymorphism is a Risk Factor for Type 2 Diabetes in a Population-Based Japanese Sample

Accession number;03A0623042

Title;The D Allele of the Angiotensin-Converting Enzyme Insertion/Deletion (I/D) Polymorphism is a Risk Factor for Type 2 Diabetes in a Population-Based Japanese Sample

Author;DAIMON M(Yamagata Univ. School Of Medicine, Yamagata, Jpn) OIZUMI T(Yamagata Univ. School Of Medicine, Yamagata, Jpn) SAITOH T(Yamagata Univ. School Of Medicine, Yamagata, Jpn) KAMEDA W(Yamagata Univ. School Of Medicine, Yamagata, Jpn) HIRATA A(Yamagata Univ. School Of Medicine, Yamagata, Jpn) YAMAGUCHI H(Yamagata Univ. School Of Medicine, Yamagata, Jpn) OHNUMA H(Yamagata Univ. School Of Medicine, Yamagata, Jpn) IGARASHI M(Yamagata Univ. School Of Medicine, Yamagata, Jpn) TOMINAGA M(Yamagata Univ. School Of Medicine, Yamagata, Jpn)

Journal Title;Endocr J

Journal Code:F0625A

ISSN:0918-8959

VOL.50;NO.4;PAGE.393-398(2003)

Figure&Table&Reference;TBL.3, REF.28

Pub. Country;Japan

Language;English

Abstract;The association of the ACE gene I/D polymorphism with type 2 diabetes (DM) was examined in a population-based Japanese sample. A total of 902 individuals (490 females and 412 males, age 58.8 .+-. 12.2 yr) from a cohort population (n = 3,706) of the Funagata diabetes study were divided into three groups according to genotype: D/D (n = 104), I/D (n = 436) and I/I (n = 362). Chi-square test and ANOVA were used for association studies and to assess the differences in the traits' values, respectively. More individuals with the genotypes D/D and I/D were diabetic (8.7% and 4.1%, respectively) than those with the genotype I/I (2.8%, p = 0.008 and p = 0.032, respectively). The genotype D/D was a risk factor for DM (relative risk (RR) 3.13, 95% CI 1.31-7.51), and also for DM and IGT (RR 1.78, 95% CI 1.14-2.76). Multiple logistic regression analysis also showed that the genotypes with the D allele were risk factors for DM and IGT even when adjusting for age, sex, hypertension and serum total cholesterol levels (odds ratio 1.49, 95% CI 1.01-2.21). The D allele of the ACE gene I/D polymorphism is a risk factor for DM. (author abst.)