Science Links Japan | Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. II. Effects of Agaricus blazei Murill and Propolis Extract on the Pharmacokinetics of Diltiazem in Rats.

Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. II. Effects of Agaricus blazei Murill and Propolis Extract on the Pharmacokinetics of Diltiazem in Rats.

Accession number;03A0407434

Title;Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. II. Effects of Agaricus blazei Murill and Propolis Extract on the Pharmacokinetics of Diltiazem in Rats.

Author;ONISHI NORIAKI(Kyotoyakudai Yaku Byoin'yakugaku) NAKAGAWA MASATO(Kyotoyakudai Yaku Byoin'yakugaku) NISHIKAWA MIDORI(Kyotoyakudai Yaku Byoin'yakugaku) YAMASHITA MASAYUKI(Kyotoyakudai Yaku Kinobunshikagaku) OTA SHUNSAKU(Kyotoyakudai Yaku Kinobunshikagaku) YOSHIOKA MUTSUNOBU(Takarazukashibyoin Yakuzaibu) KURODA KAZUO(Takarazukashibyoin Yakuzaibu) TAKARA KOJI(Kyotoyakudai Yaku Byoin'yakugaku) YOKOYAMA TERUYOSHI(Kyotoyakudai Yaku Byoin'yakugaku)

Journal Title;Foods & Food Ingred J Jpn

Journal Code:S0046A

ISSN:0919-9772

VOL.208;NO.5;PAGE.353-360(2003)

Figure&Table&Reference;FIG.3, TBL.2, REF.29

Pub. Country;Japan

Language;Japanese

Abstract;The effects of Agaricus blazei Murill(ABM) and propolis extracts, two of the most widely used herbal functional foods or dietary supplements in Japan, on the pharmacokinetics of diltiazem(DTZ), a typical probe of cytochrome P450(CYP) 3A, were examined in rats. The simultaneous addition of propolis extract to rat small intestine and liver microsomes competitively inhibited the formation of N-demethyl DTZ(MA), an active metabolite of DTZ produced by CYP3A, in a concentration-dependent manner, with an IC50 of about 0.3 and 1.3mg/ml, respectively, but ABM extract seemed to have no inhibitory effect on CYP3A activity. The pharmacokinetics of DTZ and MA after oral administration of DTZ(30mg/kg) was not affected by simultaneous treatment of ABM extract at a normal dose of 40mg/kg. However, the simultaneous oral administration of ABM extract(200mg/kg) significantly decreased the peak plasma concentration of DTZ and tended to increase the time to reach the peak concentration of DTZ or MA after oral administration of DTZ. On the other hand, the concomitant treatment of a large amount of propolis extract(20mg/kg) did not affect the pharmacokinetics of DTZ orally administered. Accordingly, it was suggested that the simultaneous oral administration of a large amount of ABM extract delayed the intestinal absorption of DTZ in rats. (author abst.)