Dose-Related Glibenclamide-Induced Hepatitis; A Case Report.
| Accession number;03A0264386 |
| Title;Dose-Related Glibenclamide-Induced Hepatitis; A Case Report. |
| Author;ICHIMIYA YUKIKO(Furuyanaikashonikaiin) FURUYA KENTARO(Furuyanaikashonikaiin) HASEGAWA ATSUSHI(Shiritsuchitoseshiminbyoin Naika) NISHIMURA MASAHARU(Hokkaido Univ., Sch. of Med., Hosp.) |
Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.46;NO.3;PAGE.241-245(2003)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We report a rare case of dose-related glibenclamide-induced liver toxicity. A 55-year-old man first diagnosed with type 2 diabetes in 1993 was treated with glibenclamide, 1.25mg/day, from November 1995. Since diabetes mellitus control became poor, we increased the dosage from 2.5 to 5mg in February 1999. After 1 month, he was hospitalized for systemic jaundice and liver dysfunction (GOT 930 IU/l, GPT 1560 IU/l, T.Bil 26.3mg dl). Liver dysfunction improved after interruption of glibenclamide therapy for 2 months. We treated him again with glibenclamide again and liver function worsened. When glibenclamide was withdrawn, liver function returned to normal. Extrahepatic biliary obstruction, infectious hepatitis, primary liver disease, and exposure to other drugs were all excluded as a cause of liver dysfunction in this case. (author abst.) |
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