| Accession number;03A0059361 |
| Title;Hepatic Regeneration after Hepatectomy and Liver Function Estimated with 99mTc-DTPA-galactosy-human Serum Albumin. |
| Author;HA-KAWA S(Kansai Med. Univ.) YOSHIDA TSUNETAKA(Kansai Med. Univ.) SOGAWA MITSUHARU(Kansai Med. Univ.) SAWADA SATOSHI(Kansai Med. Univ.) |
Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.Suppl.2;PAGE.S.301-S.305(2002)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Objective: To assess the relation between the volume and function of the liver after hepatectomy with 99mTc-diethylenetriamine pentaacetic acid-galactosyl-human serum albumin (GSA) scintigraphy. Materials and Methods: GSA scintigraphy were performed sequentially five times before and after hepatectomy in twenty-two patients (mean age, 63.5 y) with hepatocellular carcinoma. The hepatic volume with cut-off method and maximal removal rate (Rmax) with a compartment model by Kawa were introduced as indices of the morphological and functional regeneration of the liver, respectively. Results: Postoperative Rmax at day 14 reduced by 15% than that at preoperation. Inverted increase of Rmax at day 14 was observed in 10 cases (45%), which was followed by gradual decrease until 90 days. Even in this group, hepatic volume at day 14 was the lowest value during postoperative course. This discrepancy between the function and volume was more marked in the chronic hepatitis than in the liver cirrhosis. Conclusion: Temporal functional increase after hepatectomy may be caused by a short-term stimulation to the asialogycoprotein receptor in hepatocytes. (author abst.) |
