Influence of Various Drugs on Gastric Emptying in Rats and the Improving Effects of Mosapride Citrate, a Gastroprokinetic Agent.

Accession number;03A0015807
Title;Influence of Various Drugs on Gastric Emptying in Rats and the Improving Effects of Mosapride Citrate, a Gastroprokinetic Agent.
Author;YOSHIKAWA TAKASHI(Dainihonseiyaku Yakuriken)   KAWASHIMA KATSUYOSHI(Dainihonseiyaku Yakuriken)   YOSHIDA NAOYUKI(Dainihonseiyaku Yakuriken)   
Journal Title;Japanese Pharmacology & Therapeutics
Journal Code:Z0947A
ISSN:0386-3603
VOL.30;NO.11;PAGE.979-984(2002)
Figure&Table&Reference;FIG.7, REF.16
Pub. Country;Japan
Language;Japanese
Abstract;Objective: Clinically, some of the most common adverse effects induced by various drugs are gastrointestinal symptoms including anorexia, gastric pyrosis, epigastric pain, nausea and vomiting. However, the relation between gastrointestinal symptoms induced by drugs and dysfunction of gastric motility is unclear. In the present study, we investigated whether various drugs (zonisamide, pergolide mesilate, ibudilast, mexiletine hydrochloride, acarbose and sodium valproate), that have the gastrointestinal symptoms described above, delay gastric emptying in rats. Moreover, we investigated the effect of mosapride citrate, a gastroprokinetic agent, on the delay in gastric emptying induced by zonisamide and pergolide mesilate. Methods: The rats were fasted for 18 hours before all experiments. In the experiments for gastric emptying, test drugs or vehicle was orally administered 60 mm before test meal (0.05% phenol red in 1.5% aqueous methyl cellulose solution), which was given via a gastric tube (1.5 mL per animal). Fifteen minutes after administration of test meal, the stomach was removed and the amount of phenol red remaining in the stomach was measured. Results: Zonisamide, pergolide mesilate, ibudilast and mexiletine hydrochloride dose-dependently delayed gastric emptying in rats. However, acarbose and sodium valproate had no effect on gastric emptying. Mosapride citrate [0.1-3mg/kg, p.o.] dose-dependently improved the delay in gastric emptying induced by zonisamide and pergolide mesilate. Conclusions: Delay in gastric emptying may be one of the important causes of gastrointestinal symptoms induced by various drugs. Moreover, gastroprokinetic agents, such as mosapride citrate, may be useful in improving drug induced gastrointestinal side effects. (author abst.)