Effects of Polaprezinc on Indomethacin-induced Gastric Antral Ulcers in the Refed Rat. A Comparison with Other Cytoprotective Anti-ulcer Agents from the View of Gastric Mucosal Protection.

Accession number;03A0015803
Title;Effects of Polaprezinc on Indomethacin-induced Gastric Antral Ulcers in the Refed Rat. A Comparison with Other Cytoprotective Anti-ulcer Agents from the View of Gastric Mucosal Protection.
Author;MORITA HITOSHI(ZERIA Pharm. Co., Ltd., Res. & Dev. Div., JPN)   UKAWA HIDEKI(ZERIA Pharm. Co., Ltd., Res. & Dev. Div., JPN)   HORI YUKO(ZERIA Pharm. Co., Ltd., Res. & Dev. Div., JPN)   MIURA NAOYOSHI(ZERIA Pharm. Co., Ltd., Res. & Dev. Div., JPN)   YONETA TOMOYUKI(ZERIA Pharm. Co., Ltd., Res. & Dev. Div., JPN)   KURIMOTO TADASHI(ZERIA Pharm. Co., Ltd., Res. & Dev. Div., JPN)   
Journal Title;Japanese Pharmacology & Therapeutics
Journal Code:Z0947A
ISSN:0386-3603
VOL.30;NO.11;PAGE.949-954(2002)
Figure&Table&Reference;FIG.3, TBL.1, REF.14
Pub. Country;Japan
Language;Japanese
Abstract;The anti-ulcer agent polaprezine is a chelate compound consisting of zinc ions and L-carnosine, that exhibits protective actions on the gastric mucosa without exerting antisecretory activity. We investigated the protective effects of polaprezinc and other cytoprotective antiulcer agents against indomethacin-induced gastric antral ulcers in the refed rat. Furthermore, we examined the effects of indomethacin pretreatment on the protective effects of these agents against acidified-ethanol-induced gastric lesions, to elucidate their mechanism of action. Subcutaneous indomethacin (30mg/kg) injection was administered to induce gastric antral ulcer formation in refed rats. Polaprezinc (1-10mg/kg, p.o.) attenuated the progression of the indomethacin-induced ulcers in a dose-dependent manner. Although 16,16-dimetyl prostaglandin E2 (0.005mg/kg, p.o.) also attenuated progression of the indomethacin-induced ulcers, ecabet-Na (10-100mg/kg, p.o.), teprenone (10-100mg/kg, p.o.) and rebamipide (10-100mg/kg, p.o.) did not exert this effect. While the protective effects of polaprezinc and 16, 16-dimetyl prostaglandin E2 against acidified-ethanol-induced gastric lesions remained unaffected, those of ecabet-Na, teprenone and rebamipide were reduced following indomethacin pretreatment (5mg/kg, s.c.). These results suggest that the protective effects of polaprezinc against the progression of indomethacin-induced gastric antral ulcers in the refed rat is independent of the involvement of endogenous prostaglandins. Thus, polaprezinc, like prostaglandin analogs, may also have therapeutic potential against gastric mucosal damage induced by non-steroidal anti-inflammatory drugs. (author abst.)