Phenanthroindolizidine Alkaloids and Their Cytotoxicity from the Leaves of Ficus septica.

Accession number;02A0950985
Title;Phenanthroindolizidine Alkaloids and Their Cytotoxicity from the Leaves of Ficus septica.
Author;WU P-L(National Cheng Kung Univ., Tainan, Twn)   RAO K V(National Cheng Kung Univ., Tainan, Twn)   SU C-H(National Cheng Kung Univ., Tainan, Twn)   KUOH C-S(National Cheng Kung Univ., Tainan, Twn)   WU T-S(National Cheng Kung Univ., Tainan, Twn)   
Journal Title;Heterocycles
Journal Code:S0966A
ISSN:0385-5414
VOL.57;NO.12;PAGE.2401-2408(2002)
Figure&Table&Reference;FIG.2, TBL.1, REF.22
Pub. Country;Japan
Language;English
Abstract;Phenanthroindolizidine N-Oxide, ficuseptine-A (1), together with eighteen known compounds was isolated from the leaves of Ficus septica. The structures of these compounds were elucidated by spectroscopic analysis. Among them, phenanthroindolizidines, ficuseptine (1), (+)-tylophorine (4) and a mixture of (+)-tylocrebrine (5) and (+)-isotylocrebrine (6), exhibited strong cytotoxic activity against two human cancer cell lines, NUGC and HONE-1. (author abst.)