Oral Mucosa Irritation Studies of Hamsters and Gastric Mucosa Irritation Studies of Rats. (4).
| Accession number;02A0748079 |
| Title;Oral Mucosa Irritation Studies of Hamsters and Gastric Mucosa Irritation Studies of Rats. (4). |
| Author;KIGUCHI MASAO(Saf. Res. Inst. for Chem. Compound Co. Ltd., JPN) SHORIKEN KOICHI(Eisai Co., Ltd., JPN) YOKOTANI RYO(Saf. Res. Inst. for Chem. Compound Co. Ltd., JPN) KAMIYAMA NORIHITO(Saf. Res. Inst. for Chem. Compound Co. Ltd., JPN) FURUKAWA MASATOSHI(Saf. Res. Inst. for Chem. Compound Co. Ltd., JPN) IKKA TSUGUO(Saf. Res. Inst. for Chem. Compound Co. Ltd., JPN) NONAKA JUN(Sannoba) AOKI HARUO(Sannoba) NAKATA HIROSHI(Eisai Co., Ltd., JPN) |
Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.8;PAGE.603-611(2002)
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| Figure&Table&Reference;FIG.3, TBL.6, REF.4 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;This study was conducted to assess the mucosal irritative effects of the tablets (S-BRT1-TT0-1, S-ENA1-TTO-1, S-BRT-TT1-1 and S-ENA-TT1-1) on the oral mucosa of hamsters and the gastric mucosa of rats. In the oral mucosa irritation study of hamsters, where the cheek pouches were exposed to the tablets for 30 minutes under anesthesia, macro- and histo-pathological observations revealed no changes that related to the test substance at 30 minutes and 24 hours after the application. In the gastric mucosa irritation study of rats, macropathological observations revealed no changes that related to the test substance at 4 and 24 hours after the administration. These results indicate that S-BRT1-TT0-1, S-ENA1-TTO-1, S-BRT-TT1-1 and S-ENA-TT1-1 have no irritative effects on oral and gastric mucosae. (author abst.) |
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