Effects of the Antiulcer Agent Sofalcone on Monocloramine-induced Gastric Mucosal Injury in Rats.
| Accession number;02A0748078 |
| Title;Effects of the Antiulcer Agent Sofalcone on Monocloramine-induced Gastric Mucosal Injury in Rats. |
| Author;KAJITA SUMIYO(Taisho Pharm. Co., Ltd.) MURAKAMI SHIGERU(Taisho Pharm. Co., Ltd.) NAKAIKE SHIRO(Taisho Pharm. Co., Ltd.) ISOBE YOSHIHIKO(Taisho Pharm. Co., Ltd.) KIJIMA HARUKO(Taisho Pharm. Co., Ltd.) |
Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.8;PAGE.597-601(2002)
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| Figure&Table&Reference;FIG.4, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Many studies noted the involvement of hydrogen peroxide and monocloramine produced by Helicobacter pylori (Hp) infection in the pathogenesis of gastric mucosal injury. The antiulcer agent sofalcone protects against various types of experimental gastric injury. In the present study, we examined effects of sofalcone on gastric mucosal injury induced by monocloramine in rats. The oral administration of 120mM monocloramine to rats caused serious bloody lesions in the gastric mucosa, and pretreatment with sofalcone at 30, 100, and 300mg/kg suppressed such lesions in a dose-dependent manner. Taurine, the sulfur-containing amino acid with antioxidant activity at 100mg/kg, also significantly suppressed gastric lesions. In HL-60 cells, sofalcone decreased the secretion of H2O2 with an IC50 value of 82.1.MU.M. These findings show that sofalcone has antioxidant effects, hence may prove effective for treatment of subjects with gastric injuries related to Hp infection. (author abst.) |
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