| Accession number;02A0628736 |
| Title;Effects of the uricosuric action by losartan on the patients taking furosemide. |
| Author;YAMATANI AKIMASA(Kokuritsukanazawabyoin Yakuzaika) NOMURA RYOKO(Kokuritsukanazawabyoin Yakuzaika) HAYASHI MAKOTO(Kokuritsukanazawabyoin Yakuzaika) MORI YUKIO(Kokuritsukanazawabyoin Yakuzaika) SUZUKI TATSUO(Kokuritsukanazawabyoin Yakuzaika) YOSHIMURA MITSUHIRO(Kokuritsukanazawabyoin Yakuzaika) |
Journal Title;Japanese Journal of National Medical Services
|
Journal Code:F0707A
|
ISSN:0021-1699
|
|
VOL.56;NO.6;PAGE.327-330(2002)
|
| Figure&Table&Reference;FIG.3, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Angiotensin II receptor antagonist losartan potassium is demonstrated to have uricosuric effect. We investigated the usefulness of the uricosuric action in the combination therapy using losartan potassium, and furosemide increase serum uric acid concentration. Forty-nine patients with normal renal function and not having any drugs influenced on serum uric acid concentration, were randomly devised into 4 groups; F group who take furosemide monotherapy, FL group who take furosemide and losartan simultaneously, L group who take losartan monotherapy, F.RAR.L group who taking furosemide followed by losartan. As for 4 groups the serum uric acid concentration and change rate were compared of around the losartan and furosemide intake. As a result change rate of F group and FL group was increased 33.3%,21.3%, respectively. Change rate of F group was increased than FL group: however, there was no significant difference between the two groups. Change rate of L group and F.RAR.L group was decreased 2.2%,15.0%,respectively. Change rate of F.RAR.L group decreased significantly than the other groups(non pared t-test). These results suggested that uricosuric effects of losartan might a meliorated the uric acid retention effect of furosemide therapy. (author abst.) |
