Clinical Study of EN036 for Non-specific Menopausal Complaints.
| Accession number;02A0532075 |
| Title;Clinical Study of EN036 for Non-specific Menopausal Complaints. |
| Author;YOSHIOKA TAMOTSU(Center for Adult Dis., Kurashiki) NISHIUCHI TOSHIFUMI(Center for Adult Dis., Kurashiki) AKIMOTO TERUHISA(Okayama Saiseikai General Hospital) YOSHIDA NOBUTAKA(Hiroshimashiminbyoin Sanfujinka) KANESHIGE EMIKO(Okayamachuobyoin Sanfujinka) HASEGAWA YASUTAKA(Chudenbyoin Sanfujinka) KAWAHARA YOSHIFUMI(Tsuyamachuobyoin Sanfujinka) |
Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.5;PAGE.401-414(2002)
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| Figure&Table&Reference;FIG.1, TBL.12, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A clinical study was conducted to investigate the usefulness of EN036, a vitamin E (d-.ALPHA.-tocopherol) preparation containing Japanese angelica root extract and red ginseng root extract, for indefinite climacteric complaints. A total of 107 patients were studied. The main findings were as follows. 1. The improvement rating by symptom was "slightly improved" or better in 83.3% of patients for hot flashes, 64.4% for feeling of cold, 66.2% for shoulder stiffness, 63.0% for numbness in the hands and feet, 73.4% for heavy feeling in the head, 61.6% for lassitude, and 65.0% for perspiration. 2. The global improvement rating was "slightly improved" or better in 93.6% of patients. 3. Adverse reactions occurred in 10.1% of patients, and none were serious. 4. The overall safety rating showed "no problems" with safety in 90.9% of patients. 5. The drug was "slightly useful" or better in 87.8% of patients. It is concluded from the above results that EN036 is a useful drug for alleviating indefinite climacteric complaints. (author abst.) |
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