| Accession number;02A0532073 |
| Title;Effect of Roxatidine Acetate Hydrochloride on Gastritis in Mongolian Gerbils Infected with Helicobacter pylori. |
| Author;OGAWA CHISATO(Teikokuzokiseiyaku Yakurikenkyubu) TAMAOKI SATORU(Teikokuzokiseiyaku Yakurikenkyubu) YAMAMOTO TOSHIKO(Teikokuzokiseiyaku Yakurikenkyubu) TAKAHASHI NOBUYUKI(Teikokuzokiseiyaku Yakurikenkyubu) ARAKI SEIICHI(Teikokuzokiseiyaku Yakurikenkyubu) MIKODA NOBUYUKI(Asekkuyoshitomi) |
Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.5;PAGE.391-396(2002)
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| Figure&Table&Reference;FIG.5, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Helicobacter pylori (H. pylori) cause gastritis in Mongolian gerbils as well as humans. In this study, we evaluated the effect of roxatidine acetate hydrochloride (roxatidine) on gastritis in H. pylori infected Mongolian gerbils. Mongolian gerbils were inoculated orally with H. pylori (ATCC43504). From 8 weeks after the inoculation, roxatidine was administered orally to the animals twice a day at a dose of 50, 100 or 200mg/kg/day for 4 weeks. After the treatment period, stomachs were isolated, weighed and observed macroscopically, followed by histologic and bacteriologic examinations. Roxatidine did not change the number of viable bacteria. However roxatidine alleviated the gastric lesions at the doses of 100 and 200mg/kg/day. The gastric weights of these groups also decreased, which may reflect the alleviation of gastritis. Histologically, severe infiltration of inflammatory cells in the pyloric mucosa and submucosa was observed in the infected control animals. In the roxatidine treated animals, the degree of infiltration of inflammatory cells was mild. In conclusion, roxatidine alleviated gastritis in Mongolian gerbils infected with H. pylori, without showing antibacterial activity. (author abst.) |
