| Accession number;02A0462196 |
| Title;Seven Days of Intermittent Terbinafine 250 mg Treatment in Tinea Pedis. |
| Author;HAMAGUCHI TAIZO(Showadai Yokohamashihokububyoin Hifuka) TAKIUCHI IWAO(Showadai Fujigaokabyoin Hifuka) |
Journal Title;Japanese Journal of Medical Mycology
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Journal Code:G0589A
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ISSN:0916-4804
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VOL.43;NO.2;PAGE.79-83(2002)
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| Figure&Table&Reference;TBL.3, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Tinea pedis responds well to topical antifungal therapy, however, relapse of the disease is not uncommon. Long-term application of antifungals is usually necessary to control relapse. We conducted an open trial of a 7 day intermittent course of oral terbinafine treatment at 250 mg/day for plantar type and interdigital type of tinea pedis. Seventy-five patients of plantar type and 49 patients of interdigital tinea pedis were treated with a 7 day course of terbinafine 250 mg/day. Clinical assessments were made at baseline and every 4 weeks. Another 7 day course of the same amount of terbinafine were given depending on the clinical and the mycological response. Of the 75 plantar type tinea pedis with 8 patients excluded, 66 of the remaining 67(98.5%) were evaluated as cured. Of the 49 interdigital tinea pedis (3 excluded), 43 of 46 patients (93.5%) cured. Relapse of the disease was observed in 4 of 51 patients at 1 year after treatment, 4 of 25 at 2 years, and 2 of 9 at 3 years in the plantar type, and in 4 of 30 at 1 year, 0 of 14 at 2 years, and 0 of 6 at 3 years in the interdigital tinea pedis group. Intermittent terbinafine therapy is thus effective in the treatment of tinea pedis. (author abst.) |
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