A Case of Atopic Cough (Eosinophilic Bronchitis) in Which Epinastine Hydrochloride Significantly Reduces Persistent Cough.

Accession number;02A0404958
Title;A Case of Atopic Cough (Eosinophilic Bronchitis) in Which Epinastine Hydrochloride Significantly Reduces Persistent Cough.
Author;SHIOYA TAKANOBU(Akitadaigakuiryogitandai Rigakuryohogakka)   SATAKE MASAHIRO(Akitadaigakuiryogitandai Rigakuryohogakka)   SANO MASAAKI(Akita Univ., Sch. of Med.)   KAGAYA MANABU(Akita Univ., Sch. of Med.)   ITO TAKEFUMI(Akita Univ., Sch. of Med.)   WATANABE AKIKO(Akita Univ., Sch. of Med.)   FUKUI SHIN(Akita Univ., Sch. of Med.)   SASAKI MASAHIRO(Akita Univ., Sch. of Med.)   MIURA MAMORU(Akita Univ., Sch. of Med.)   
Journal Title;Japanese Pharmacology & Therapeutics
Journal Code:Z0947A
ISSN:0386-3603
VOL.30;NO.3;PAGE.245-249(2002)
Figure&Table&Reference;FIG.2, TBL.2, REF.20
Pub. Country;Japan
Language;Japanese
Abstract;Atopic cough (eosinophilic bronchitis) is a newly defined disease in which chronic cough, increased cough hypersensitivity and normal bronchial hypersenstivity were featured. We report a case of atopic cough in which long-acting selective H1 antagonist, epinastine hydrochloride was significantly effective on persistent non-productive cough. A 36-year-old female patient with chronic persistent cough was diagnosed as atopic cough. Epinastine hydrochloride (epinastine, 20mg/day) was administered, and we evaluated cough scores, medication scores, pulmonary function, capsaicin cough threshold, bronchial hyperresonsiveness(BHR) to methacholine(MCh), before and after 4-week treatment with epinastine. Treatment with epinastine resulted in a marked decrease in persistent cough and in a marked improvement in capsaicin cough threshold and no improvement in BHR. These results suggested that epinastine hydrochloride may be useful for treating patients with atopic cough, however further clnical investigation is warranted to verify the mechanism and the pathophysiology of atopic cough. (author abst.)