| Accession number;02A0292801 |
| Title;Effect of Epinastine Hydrochloride(Alesion) on the Central Nervous System. |
| Author;KAMEI CHIAKI(Okayamadai Yaku Yakubutsugaku) NISHIGA MIYUKI(Okayamadai Yaku Yakubutsugaku) SHIGEMOTO YUKI(Okayamadai Yaku Yakubutsugaku) KONISHI MASAKO(Okayamadai Yaku Yakubutsugaku) SHINOMIYA KAZUAKI(Okayamadai Yaku Yakubutsugaku) |
Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.2;PAGE.91-95(2002)
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| Figure&Table&Reference;FIG.2, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50mg/kg, p.o. In contrast, olopatadine at 50mg/kg and ketotifen at 10mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20mg/kg and 10mg/kg, respectively. (author abst.) |
