| Accession number;02A0292800 |
| Title;Effects of Intake of Nigerooligosaccharides-supplemented Syrup on the Immune Function and Quality of Life in Healthy Young Adult Subjects. |
| Author;MUROSAKI SHINJI(Takedashokuhinkogyo Kenkyukaihatsubu) IKEMATSU HIDEYUKI(Haradoibyoin Rinshokenkyubu) HIROSE YOSHITAKA(Takedashokuhinkogyo Kenkyukaihatsubu) YAMAMOTO YOSHIHIRO(Takedashokuhinkogyo Kenkyukaihatsubu) YUKAMI SUSUMU(Seizonkankyokagakuken) NOMOTO KIKUO(Kyushu Univ.) |
Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.2;PAGE.81-90(2002)
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| Figure&Table&Reference;FIG.8, TBL.2, REF.22 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Background We have shown that nigerooligosaccharides(NOS), an immunopotentiating foodstuff comprised of nigerose and nigerosylmaltooligosaccharides, has beneficial effects on health related QOL as well as immune function in the healthy elderly. Objective To study the effects of NOS-supplemented syrup on the immune function and the health related QOL in healthy young adult subjects. Methods A randomized, single-blind, placebo-controlled, parallel-group study comprising 22 healthy subjects(1 man and 21 women, aged 20-40 years) was carried out. The subjects were randomized to receive 10g/day of NOS-supplemented syrup or matching syrup for 12 weeks, followed by a 4-week wash-out period. Blastogenesis and cytokine productions induced by concanavalin A(Con A) and OK-432 and natural killer(NK) activity of peripheral blood mononuclear cells were measured every 4 weeks. Health-related QOL was assessed using a self-rating questionnaire with 24 items. Results Con A-induced blastogenesis in NOS group was significantly higher(p=0.008) during the dietary period than that during the non-dietary period, when it was normalized by control mean measurement at respective time point. It was also higher than that in control group during the dietary period and returned to the baseline level after the wash-out period in percentage increases from baseline(at week 0). OK-432-induced blastogenesis and Con A- and OK-432-induced cytokine productions were not different within NOS group and between groups. Although NK activity in NOS group significantly decreased during the dietary period as well as after the wash-out period compared with control group, its decrease was partial within NOS group. Health-related QOL was not different within group and between groups.... (author abst.) |
