| Accession number;01A0903152 |
| Title;Study on dehydration and crystallization behavior of nitrofurantoin monohydrate by CRTG and humidity controlled XRD-DSC. |
| Author;KISHI A(Rigaku Corp.) ARII T(Rigaku Corp.) MUNEKAWA S(Rigaku Corp.) OTSUKA M(Kobe Pharmaceutical Univ.) MATSUDA Y(Kobe Pharmaceutical Univ.) |
Journal Title;Netsu Sokutei Toronkai Koen Yoshishu
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Journal Code:F0840B
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ISSN:
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VOL.36th;NO.;PAGE.30-31(2000)
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| Figure&Table&Reference;FIG.3, REF.1 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The dependence of thermal dehydration and crystallization behavior of nitrofurantoin monohydrate on humidity was studied by using humidity controlled XRD-DSC. Dehydration and crystallization behavior in dry and high humidity behavior was quite different. Dehydration in dry nitrogen gave a mixture of crystalline and amorphous anhydrate at 124-180.DEG.C. followed by crystallization around 185-190.DEG.C.. Whereas, dehydration in high humidity atmosphere such as 17.7%H2O(60.DEG.C.90%RH) gave well crystalline anhydrate at 140.DEG.C.. The thermogravimetric analysis of dehydration gave the activation energy of 112kJ/mol. (author abst.) |
