Usefulness of Paired Estimation of Fasting Plasma Glucose and HbA1c: A Long-term Follow-up Study of Screened Nondiabetic Subjects.

Accession number;01A0986216
Title;Usefulness of Paired Estimation of Fasting Plasma Glucose and HbA1c: A Long-term Follow-up Study of Screened Nondiabetic Subjects.
Author;TAKAHASHI MASAKI(Fujiwakai Fujimabyoin Sogokenshinshisutemu)   KAJI KIYOYUKI(Fujiwakai Fujimabyoin Sogokenshinshisutemu)   TOGASHI ATSUHITO(Fujiwakai Fujimabyoin Sogokenshinshisutemu)   OGINO YOSHIO(Fujiwakai Fujimabyoin Sogokenshinshisutemu)   SHIBOSAWA TOSHIYUKI(Fujiwakai Fujimabyoin Sogokenshinshisutemu)   KAWAZU SHOJI(Saitamaidai Sogoiryose Kenkokanrika・daiichinaika)   
Journal Title;Journal of the Japan Diabetic Society
Journal Code:Z0279B
ISSN:0021-437X
VOL.44;NO.9;PAGE.745-750(2001)
Figure&Table&Reference;FIG.3, TBL.3, REF.9
Pub. Country;Japan
Language;Japanese
Abstract;In a retrospective study, we followed up 292 nondiabetic subjects monitored by fasting plasma glucose (FPG) over 3 years and analyzed their incidence of diabetes. On their first examination at Toma Hospital in 1985-1990, HbA1c was measured and oral glucose tolerance test (OGTT) undertaken. Of the 292, 102 had normal glucose tolerance (NGT) and 190 impaired glucose tolerance (IGT). The ROC plot for HbA1c revealed that 5.6% the most appropriate cutoff for predicting progression to diabetes. Accordingly, subjects were classified into 3 groups based on baseline FPG (.GEQ.110 mg/dl, 100-109 mg/dl, .LEQ.99 mg/dl) and into 2 groups based on baseline HbA1c (.GEQ.5.6%, .LEQ.5.5%). Diabetes was defined as FPG.GEQ.126 mg/dl. Cumulative incidence of diabetes from each FPG group was higher in the group with FPG.GEQ.110 mg/dl than in that with FPG 100-109 mg/dl or .LEQ.99 mg/dl. Cumulative incidence of diabetes in combined FPG and HbA1c groups was higher in the group with HbA1c.GEQ.5.6% than in that with HbA1c.LEQ.5.5%, regardless of FPG. The incidence of diabetes in subjects whose insulinogenic index (I. I.) was .DELTA. IRI/.DELTA. PG (30-0 min) was <0.4 were higher in the group with HbA1c.GEQ.5.6% than in that in that with HbA1c.LEQ.5.5%, regardless of FPG. In conclusion, for screened nondiabetic subjects, the use of paired FPG and HbA1c helps to identify potential diabetic subjects. (author abst.)