Science Links Japan | Microbial production of anticancer drug etoposide from insecticidal active substance Deoxypodophyllotoxin (DPT). Studied from nature and learning from human.

Microbial production of anticancer drug etoposide from insecticidal active substance Deoxypodophyllotoxin (DPT). Studied from nature and learning from human.

Accession number;01A0447840

Title;Microbial production of anticancer drug etoposide from insecticidal active substance Deoxypodophyllotoxin (DPT). Studied from nature and learning from human.

Author;INAMORI YOSHIHIKO(Osakayakudai Daiichibiseibutsugaku) KATO YOSHIAKI(San-ei Gen F.F.I., Inc.)

Journal Title;Medicine & Drug Journal

Journal Code:Z0650A

ISSN:0287-4741

VOL.37;NO.4;PAGE.1350-1356(2001)

Figure&Table&Reference;FIG.4, TBL.3, REF.12

Pub. Country;Japan

Language;Japanese

Abstract;This paper describes microbial production of anticancer drug etoposide from insecticidal active substance deoxypodophyllotoxin (DPT). Strong insecticidal activity in component of Anthrtscus sylvestris, DPT was found. DPT is a deoxy form of epipodophyllotoxin, a basic skeleton of the anticancer drug etoposide. Penicillium F-0543 converts DPT into the epipodophyllotoxin at 100% yield. Since seeds of Hernandia ovigera of Okinawa contain 2.4% of DPT, hydroxylation reaction of DPT may have the possibility of connecting for mass production of etoposide.