Influence of Estradiol-17.BETA. on Medaka, Orizias latipes. A model of screening for the endocrine disruptors.
| Accession number;01A0400202 |
| Title;Influence of Estradiol-17.BETA. on Medaka, Orizias latipes. A model of screening for the endocrine disruptors. |
| Author;HATAKEYAMA HITOSHI(Nippon Vet. and Anim. Sci. Univ.) MINAKAWA TOMOKO(Nippon Vet. and Anim. Sci. Univ.) HARADA TAKAHIKO(Nippon Vet. and Anim. Sci. Univ.) |
Journal Title;Bulletin of Nippon Veterinary and Animal Science University
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Journal Code:S0144B
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ISSN:0373-8361
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VOL.;NO.49;PAGE.33-39(2000)
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| Figure&Table&Reference;FIG.7, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Medakas (Orizias latipes) were exposed to Bisphenol A(BP) and Dibutyl phthalate(DP) in our previous studies. In BP-treated medakas, testis-ova and renal injuries were found. In DP-treated medakas, hepatic insults were observed. Those results demonstrated that the exposure to a natural estorogen may be necessary for elucidating the effects of BP and DP. In this study, therefore, medakas were exposed to Estradiol-17.BETA. (1.5ppm) for 10 days, and examined by light and electron microscopy. In male medakas, testis-ova (on the 7 weeks), and increase of connective tissue (from 2 week later) were found in the testis. In the kidney, glomeruli accumulating proteinous substances were observed. These changes, however, gradually decresed during the course of the study. In female medakas, the growth of oocytes decreased. Renal injuries were similar to those seen in male medakas. These changes were more rapid and incremental than those of BP- and DP-treated medakas. Taken together, these results suggest that the exposure studies of Estradiol-17.BETA. to medakas could be used as the positive contorol for the endocrine disruptors screenings. (author abst.) |
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