The Role of Nitrergic System in Lidocaine-Induced Convulsion in the Mouse.
| Accession number;01A0315489 |
| Title;The Role of Nitrergic System in Lidocaine-Induced Convulsion in the Mouse. |
| Author;KURT M(Ondokuz Mayis Univ., Turkey) BILGE S S(Ondokuz Mayis Univ., Turkey) KUKULA O(Ondokuz Mayis Univ., Turkey) KESIM Y(Ondokuz Mayis Univ., Turkey) CELIK S(Ondokuz Mayis Univ., Turkey) |
Journal Title;Jpn J Pharmacol
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Journal Code:G0813A
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ISSN:0021-5198
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VOL.85;NO.1;PAGE.92-94(2001)
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| Figure&Table&Reference;TBL.1, REF.23 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The effects of N-nitro-L-arginine-methyl ester(L-NAME) a nitric oxide(NO) synthase inhibitor and L-arginine, a NO precursor, were investigated on lidocaine-induced convulsions. In the first experiment, four groups of mice received physiological saline(0.9%), L-arginine(300mg/kg, i.p.), L-NAME(100mg/kg, i.p.) and diazepam(2mg/kg), respectively. Thirty minutes after these injections, all mice received lidocaine(50mg/kg, i.p.). In the second experiment, four groups of mice received similar treatment in the first experiment, and 30min after these injections, all mice received a higher dose of lidocaine(80mg/kg). L-NAME(100mg/kg, i.p.) and diazapam(2mg/kg) significantly decreased the incidence of lidocaine(50mg/kg)-induced convulsions. In contrast, the L-arginine treatment increased the incidence of lidocaine(80mg/kg, i.p.)-induced convulsions significantly. These results may suggest that NO is a proconvulsant mediator in lidocaine-induced convulsions. (author abst.) |
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