Cytotoxic Pregnanes from Leaves of Adenium obesum.

Accession number;00A0682738
Title;Cytotoxic Pregnanes from Leaves of Adenium obesum.
Author;NAKAMURA M(Chiba Univ., Chiba, Jpn)   ISHIBASHI M(Chiba Univ., Chiba, Jpn)   OKUYAMA E(Chiba Univ., Chiba, Jpn)   KOYANO T(Temko Corp., Tokyo, Jpn)   KOWITHAYAKORN T(Khon Kaen Univ., Khon Kaen, Tha)   HAYASHI M(Kitasato Inst., Tokyo, Jpn)   KOMIYAMA K(Kitasato Inst., Tokyo, Jpn)   
Journal Title;Nat Med
Journal Code:G0625A
ISSN:1340-3443
VOL.54;NO.3;PAGE.158-159(2000)
Figure&Table&Reference;TBL.1, REF.12
Pub. Country;Japan
Language;English
Abstract;Two pregnanes possessing a 16-en-20-one system were isolated from the leaves of Adenium obesum, which exhibited a cytotoxic activity against murine leukemia P388/S cells. Their 16,17-dihydro derivatives proved to be not cytotoxic. (author abst.)