Synthesis of 5-substituted indole derivatives, Part II. Synthesis of sumatriptan through the Japp-Klingemann reaction.
| Accession number;00A0303074 |
| Title;Synthesis of 5-substituted indole derivatives, Part II. Synthesis of sumatriptan through the Japp-Klingemann reaction. |
| Author;PETE B(Technical Univ. Budapest, Budapest, Hun) BITTER I(Technical Univ. Budapest, Budapest, Hun) HARSANYI K(Gedeon Richter Ltd., Budapest, Hun) TOKE L(Technical Univ. Budapest, Budapest, Hun) |
Journal Title;Heterocycles
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Journal Code:S0966A
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ISSN:0385-5414
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VOL.53;NO.3;PAGE.665-673(2000)
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| Figure&Table&Reference;REF.13 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Synthesis of selective 5-HT1B/1D receptor agonist, sumatriptan(1) was accomplished through decarboxylation of 2-carboxy-3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide(2) in quinoline with copper powder. The preparation of the acid(2) was effected through the Japp-Klingemann method thus avoiding the need for the formation of hydrazine from diazonium salt. Attempted decarboxylation in N,N-dimethylacetamide resulted in the formation of the .BETA.-carboline(16). (author abst.) |
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