Inhibitory effects of hot water extract from Agaricus blazei fruiting bodies (CJ-01) on hypertension development in Spontaneously Hypertensive Rats.

Accession number;00A0165843
Title;Inhibitory effects of hot water extract from Agaricus blazei fruiting bodies (CJ-01) on hypertension development in Spontaneously Hypertensive Rats.
Author;EGUCHI FUMIO(Tokyo Univ. of Agric.)   WATANABE YASUO(Tokyo Medical College)   ZHANG J(Shinappusu)   MIYAMOTO KOJI(Yamaguchi Univ., Sch. of Med.)   YOSHIMOTO HIROAKI(Nihombaio)   FUKUHARA TOMIO(Tokyo Medical College)   HIGAKI MIYATO(Tokyo Univ. of Agric.)   
Journal Title;Journal of Traditional Medicines
Journal Code:Y0941A
ISSN:1340-6302
VOL.16;NO.5;PAGE.201-207(1999)
Figure&Table&Reference;FIG.2, TBL.3, REF.12
Pub. Country;Japan
Language;Japanese
Abstract;Inhibitory effects of Agaricus blazei fruit hot water extract (CJ-01) on the development of hypertension in Spontaneously Hypertensive Rats(SHR) were examined. Marked hypertension occurs in 8-week old SHR and a significant increase in hypertension is shown in 10-week old SHR. Maximum hypertension occurs in 20-week old SHR. The development of hypertension seen in SHR was measured by means of the Tail Cuff method and blood/urine examinations. CJ-01 (10g/600ml) was extracted at 80.DEG.C. for 1hr and several dosages (3 to 15g/60kg/day) were freely given to SHR and normotensive (WKY) rats. Animals were divided into five groups: 1) CJ-01 untreated WKY(WKY-Con), 2) CJ-01 treated WKY from 8th week after birth (WKY-Pre), 3) CJ-01 untreated SHR(SHR-Con), 4) CJ-01 treated SHR from 8th week after birth (SHR-Pre), 5) CJ-01 treated SHR from 10th week after birth (SHR-Post). All results obtained from WKY-Con and WKY-Pre were identical, although these data were significantly different from those of SHR-Con. In the SHR-Pre group, dosages between 6 and 12g/60kg/day of CJ-01 significantly blocked the development of hypertension and improved the results of blood and urine examinations, particularly creatinine level, A/G ratio, total cholesterol, urine excretion and so on. Also, the SHR-Post group exhibited a significant reduction in hypertension after 40 days of treatment, although the same dosage did not effect WKY animals. Thus CJ-01 may have prophylactic and/or therapeutic effects on hypertension and hypertensive disease. (author abst.)